Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma
نویسندگان
چکیده
منابع مشابه
Merkel cell polyomavirus and cutaneous Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine skin cancer of elderly patients. Generally, it originates from Merkel cells of the basal layer of the epidermis characterized by typical neuroendocrine granules (neuron-specific enolase; NSE+) and keratin filament (cytokeratin-20; CK20). Its incidence has been increasing in the last two decades, likely because of improved ability t...
متن کاملMerkel Cell Polyomavirus and Merkel Cell Carcinoma, France
of the fi rst diagnosed case (in Spain) in a human with aseptic meningitis.lence of West Nile virus neutralizing an-tibodies in colonial aquatic birds in southern Spain. and performance testing of quantitative real time PCR assays for infl uenza A and B viral load measurement. Detection and differentiation of pathoge-nicity of avian paramyxovirus serotype 1 from fi eld cases using one-step reve...
متن کاملDigital Merkel cell carcinoma.
Merkel cell carcinoma (MCC) is a rare and biologically aggressive neuroendocrine tumour of the skin. Recent analysis of a surveillance, epidemiology and end results program has shown a statistically significant increase of 8% per year in the age-adjusted rates for MCC of the skin over the past 15 years. MCC commonly presents as a painless, rapidly growing, single red or purple cutaneous nodule....
متن کاملMerkel cell carcinoma
BACKGROUND Merkel cell carcinoma (MCC) is an unusual primary neuroendocrine carcinoma of the skin. MCC is a fatal disease, and patients have a poor chance of survival. Moreover, MCC lacks distinguishing clinical features, and thus by the time the diagnosis is made, the tumour usually have metastasized. MCC mainly affects sun-exposed areas of elderly persons. Half of the tumours are located in t...
متن کاملMerkel Cell Polyomavirus Strains in Patients with Merkel Cell Carcinoma
We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2014
ISSN: 0906-6705
DOI: 10.1111/exd.12546